The macrophage and tick vaccine laboratory studies the interaction between athropod vectors, infectious microorganisms and their mammalian hosts. The laboratory is primarily focused on ticks of the genus Ixodes, which transmit several medically important pathogens, such as the causative agent of Lyme borreliosis, Borrelia burgdorferi.
The lab participates in a large multicenter project funded by the EU (ANTIDotE) that seeks to identify tick salivary antigens that could be used as potential vaccine candidates against tick bites and therefore, prevent the transmission of pathogens. They are also interested in the pharmacological activities exerted by tick saliva proteins, especially those that can modulate the immune response and that can have therapeutic applications in immune disorders.
Finally, the group is interested in understanding the regulation of the immune response pathways present in ticks that participate in the control of pathogens within the vector. On the other hand, the laboratory seeks to understand the response of macrophages to infectious agents, from Lyme borreliosis to inflammatory bowel disease to tuberculosis.
They are interested in understanding the metabolic control of macrophage responses through the specific mitochondrial complex I repressor, MCJ in different models of disease in which these cells participate, such as Lyme carditis and inflammatory bowel disease. Furthermore, the role of INFγ and other signals on the plasticity of the response of macrophages to infectious agents is another focus of the laboratory.
Finally, the group is interested in defining the phagocytic ‘ome’ that mediates the uptake, elimination and initiation of proinflammatory responses by macrophages. In this context, the group described the Complement Receptor (CR) 3 as a phagocytic receptor involved in the elimination of B. burgdorferi by macrophages. CR3 cooperates with the GPI-anchored protein, CD14, in the internalization of the spirochete, a novel mechanism that is independent of MyD88 signals.
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Principal Investigator
Juan Anguita
Ikerbasque Research Professor RESEARCH ASSISTANT -
Hector Rodriguez
TECHNICIANS / DOCTORAL CANDIDATES -
Ainhoa Palacios
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Itziar Martín Ruíz
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Samuel Tanner Pasco
MSCA-ITN Fellow -
Iratxe Seoane Alvarez
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Sarai Araujo Aris
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Alba Mosteiro Couso
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Naiara Gutiez García
AECC Predoctoral Felow
Members
Latest Publications
Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen
Pifferi, C;Aguinagalde, L;Ruiz-de-Angulo, A;Sacristan, N;Baschirotto, PT;Poveda, A;Jimenez-Barbero, J;Anguita, J;Fernandez-Tejada, A
CHEMICAL SCIENCE
2023-03-01
New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants
Romerio, A;Gotri, N;Franco, AR;Artusa, V;Shaik, MM;Pasco, ST;Atxabal, U;Matamoros-Recio, A;Minguez-Toral, M;Zalamea, JD;Franconetti, A;Abrescia, NGA;Jimenez-Barbero, J;Anguita, J;Martin-Santamaria, ...
JOURNAL OF MEDICINAL CHEMISTRY
2023-02-02
New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants
Romerio, A;Gotri, N;Franco, AR;Artusa, V;Shaik, MM;Pasco, ST;Atxabal, U;Matamoros-Recio, A;Minguez-Toral, M;Zalamea, JD;Franconetti, A;Abrescia, NGA;Jimenez-Barbero, J;Anguita, J;Martin-Santamaria, ...
JOURNAL OF MEDICINAL CHEMISTRY
2023-02-02
Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development
Rana, VS;Kitsou, C;Dutta, S;Ronzetti, MH;Zhang, M;Bernard, Q;Smith, AA;Tomas-Cortazar, J;Yang, XL;Wu, MJ;Kepple, O;Li, WZ;Dwyer, JE;Matias, J;Baljinnyam, B;Oliver, JD;Rajeevan, N;Pedra, JHF;Narasimhan, ...
SCIENCE
2023-01-12
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
Gonzalez-Recio, I;Simon, J;Goikoetxea-Usandizaga, N;Serrano-Macia, M;Mercado-Gomez, M;Rodriguez-Agudo, R;Lachiondo-Ortega, S;Gil-Pitarch, C;Fernandez-Rodriguez, C;Castellana, D;Latasa, MU;Abecia, ...
NATURE COMMUNICATIONS
2022-11-25
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Juarez-Fernandez, M;Goikoetxea-Usandizaga, N;Porras, D;Garcia-Mediavilla, MV;Bravo, M;Serrano-Macia, M;Simon, J;Delgado, TC;Lachiondo-Ortega, S;Martinez-Florez, S;Lorenzo, O;Rincon, M;Varela-Rey, ...
HEPATOLOGY
2022-09-12
Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis
Pena-Cearra, A;Pascual-Itoiz, MA;Lavin, JL;Fuertes, M;Martin-Ruiz, I;Castelo, J;Palacios, A;Barriales, D;Fullaondo, A;Aransay, AM;Rodriguez, H;Anguita, J;Abecia, L
SCIENTIFIC REPORTS
2022-06-15
Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants
Fuentes, R;Aguinagalde, L;Pifferi, C;Plata, A;Sacristan, N;Castellana, D;Anguita, J;Fernandez-Tejada, A
FRONTIERS IN IMMUNOLOGY
2022-05-06
Resazurin-based high-throughput screening method for the discovery of dietary phytochemicals to target microbial transformation of l-carnitine into trimethylamine, a gut metabolite associated with cardiovascular disease
Simo, C;Fornari, T;Garcia-Risco, MR;Pena-Cearra, A;Abecia, L;Anguita, J;Rodriguez, H;Garcia-Canas, V
FOOD & FUNCTION
2022-04-12
Structural Analysis of the Black-Legged Tick Saliva Protein Salp15
Chaves-Arquero, B;Persson, C;Merino, N;Tomas-Cortazar, J;Rojas, AL;Anguita, J;Blanco, FJ
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022-03-01