Elsa Natividad Astorga Simón
Elsa Natividad Astorga Simón
DOCTORAL CANDIDATE
Membrane Trafficking Lab
Address: Bizkaia Science and Technology Park, building 800, Derio (Bizkaia)

Living cells constantly recycle receptors, proteins and lipids with a direct impact on nutrient uptake, re-sensitisation to environmental signals, immune surveillance and waste management. Failure to recycle results in reduced signalling, oxidative stress, protein mislocalisation and aggregation, which are pathological hallmarks of many cardiovascular, cancer, and neurodegenerative diseases. Endosomes are key recycling compartments where the biosynthetic and endocytic pathways intersect. Here, the fate of sorting receptors is directly linked to their selective recruitment into tubulo-vesicular carriers. Our understanding of receptor recycling in a motif-dependent manner, the formation of such tubulo-vesicles and the functional components defining their architecture remains very limited. Retromer is a novel protein coat complex with a central role in multiple receptor-sorting events in the endosomes. Retromer combines receptor recruitment with membrane tubulation properties, but unlike other classical coats, it does so through a single-layer or “cage-free” organization.

This laboratory is interested in understanding how retromer components form a coat around tubulo-vesicles, how transmembrane receptors are selectively recruited to control essential cell processes, and how certain pathogens subvert and co-opt these interactions.

Latest Publications

Editorial: Energy Requirements in Membrane Trafficking

Guardia, CM;Hierro, A;Gershlick, DC

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2021-10-14

Structural insight into the membrane targeting domain of theLegionella deAMPylase SidD

Tascon, I;Li, X;Lucas, M;Nelson, D;Vidaurrazaga, A;Lin, YH;Rojas, AL;Hierro, A;Machner, MP

PLOS PATHOGENS

2020-08-01

VPS29, a tweak tool of endosomal recycling

Banos-Mateos, S;Rojas, AL;Hierro, A

CURRENT OPINION IN CELL BIOLOGY

2019-08-01

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

Lin, YH;Lucas, M;Evans, TR;Abascal-Palacios, G;Doms, AG;Beauchene, NA;Rojas, AL;Hierro, A;Machner, MP

PLoS pathogens

2018-02-01

Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL

Romano-Moreno, M;Rojas, AL;Williamson, CD;Gershlick, DC;Lucas, M;Isupov, MN;Bonifacino, JS;Machner, MP;Hierro, A

Proceedings of the National Academy of Sciences of the United States of America

2017-12-26

Retromer

Lucas, M;Hierro, A

Current biology : CB

2017-07-24

Structural Mechanism for Cargo Recognition by the Retromer Complex

Lucas, M;Gershlick, DC;Vidaurrazaga, A;Rojas, AL;Bonifacino, JS;Hierro, A

Cell

2016-12-01

Role of cholesterol in SNARE-mediated trafficking on intracellular membranes

Enrich, C;Rentero, C;Hierro, A;Grewal, T

Journal of cell science

2015-03-15

Formation of Tubulovesicular Carriers from Endosomes and Their Fusion to the trans-Golgi Network

Hierro, A;Gershlick, DC;Rojas, AL;Bonifacino, JS

International review of cell and molecular biology

2015-01-01

Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5

Lucas, M;Gaspar, AH;Pallara, C;Rojas, AL;Fernandez-Recio, J;Machner, MP;Hierro, A

Proceedings of the National Academy of Sciences of the United States of America

2014-08-26