Latest Publications
2020
2019
2018
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2014
The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:
- Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
- Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
- Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
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Principal Investigator
Arkaitz Carracedo
ERC Consolidator Grant - Ikerbasque Research Professor -
Associate Principal Investigator
Edurne Berra
IKERBASQUE RESEARCH FELLOW -
Isabel Mendizabal
Ikerbasque Research Fellow -
RESEARCH ASSISTANT
Marco Piva
Ikerbasque Research Fellow -
Natalia Martín Martín
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POST DOCTORAL RESEARCHER
Amaia Zabala Letona
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Verónica Torrano
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Ianire Astobiza
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Laura Camacho
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Amaia Arruabarrena Aristorena
Juan de la Cierva Fellow -
Ana Talamillo
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Amaia Ercilla Eguiarte
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Laura Bozal Basterra
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TECHNICIANS / EARLY STAGE RESEARCHER
Leire Moreno Cugnon
Juan de la Cierva Fellow -
Jana Crespo Trives
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Pilar Castellnou Arenas
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Encarnación Pérez Andrés
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Jon Corres Mendizabal
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Cristina Viera Bardon
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Sonia Fernández Ruiz
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Alice Macchia
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Lucía Fadón
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Maider Fagoaga Eugui
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Kathrin Keim
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Ainara Martinez Gonzalez
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Mikel Pujana Vaquerizo
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Laura Martínez Pérez
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Onintza Carlevaris
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Nerea Sahuquillo Virtus
Members
Latest Publications
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...
CANCERS
2020-09-01
Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling
Figueiredo, AM;Villacampa, P;Dieguez-Hurtado, R;Lozano, JJ;Kobialka, P;Cortazar, AR;Martinez-Romero, A;Angulo-Urarte, A;Franco, CA;Claret, M;Aransay, AM;Adams, RH;Carracedo, A;Graupera, M
CIRCULATION
2020-08-18
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome
Bozal-Basterra, L;Gonzalez-Santamarta, M;Muratore, V;Bermejo-Arteagabeitia, A;Da Fonseca, C;Barroso-Gomila, O;Azkargorta, M;Iloro, I;Pampliega, O;Andrade, R;Martin-Martin, N;Branon, TC;Ting, ...
ELIFE
2020-06-18
H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer
Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...
JOURNAL OF PROTEOME RESEARCH
2020-06-05
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...
JOURNAL OF EXPERIMENTAL MEDICINE
2020-06-01
OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress
Feu, S;Unzueta, F;Llopis, A;Semple, JI;Ercilla, A;Guaita-Esteruelas, S;Jaumot, M;Freire, R;Agell, N
FASEB JOURNAL
2020-05-01
CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo
Alajati, A;D'Ambrosio, M;Troiani, M;Mosole, S;Pellegrini, L;Chen, JJ;Revandkar, A;Bolis, M;Theurillat, JP;Guccini, I;Losa, M;Calcinotto, A;De Bernardis, G;Pasquini, E;D'Antuono, R;Sharp, ...
JOURNAL OF CLINICAL INVESTIGATION
2020-05-01
Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media
Plou, J;Garcia, I;Charconnet, M;Astobiza, I;Garcia-Astrain, C;Matricardi, C;Mihi, A;Carracedo, A;Liz-Marzan, LM
ADVANCED FUNCTIONAL MATERIALS
2020-03-05
The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer
Sole, C;Goicoechea, I;Goni, A;Schramm, M;Armesto, M;Arestin, M;Manterola, L;Tellaetxe, M;Alberdi, A;Nogueira, L;Roumiguie, M;Lopez, JI;Jaka, JPS;Urruticoechea, A;Vergara, I;Loizaga-Iriarte, ...
CANCERS
2020-02-22
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Ercilla, A;Benada, J;Amitash, S;Zonderland, G;Baldi, G;Somyajit, K;Ochs, F;Costanzo, V;Lukas, J;Toledo, L
CELL REPORTS
2020-02-18
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TECHNICIANS / EARLY STAGE RESEARCHER
Monika Gonzalez
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Ana M Aransay
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Laura Bárcena
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Nuria Macias
Members
SPECIALISTLatest Publications
Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules
Royo, F;Azkargorta, M;Lavin, JL;Clos-Garcia, M;Cortazar, AR;Gonzalez-Lopez, M;Barcena, L;del Portillo, HA;Yanez-Mo, M;Marcilla, A;Borras, FE;Peinado, H;Guerrero, I;Vales-Gomez, M;Cereijo, U;Sardon, ...
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2021-01-12
Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
Barriales, D;Martin-Ruiz, I;Carreras-Gonzalez, A;Montesinos-Robledo, M;Azkargorta, M;Iloro, I;Escobes, I;Martin-Mateos, T;Atondo, E;Palacios, A;Gonzalez-Lopez, M;Barcena, L;Cortazar, AR;Cabrera, ...
PLOS BIOLOGY
2021-01-01
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
Shahrouzi, P;Astobiza, I;Cortazar, AR;Torrano, V;Macchia, A;Flores, JM;Niespolo, C;Mendizabal, I;Caloto, R;Ercilla, A;Camacho, L;Arreal, L;Bizkarguenaga, M;Martinez-Chantar, ML;Bustelo, XR;Berra, ...
CANCERS
2020-09-01
Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling
Figueiredo, AM;Villacampa, P;Dieguez-Hurtado, R;Lozano, JJ;Kobialka, P;Cortazar, AR;Martinez-Romero, A;Angulo-Urarte, A;Franco, CA;Claret, M;Aransay, AM;Adams, RH;Carracedo, A;Graupera, M
CIRCULATION
2020-08-18
H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer
Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...
JOURNAL OF PROTEOME RESEARCH
2020-06-05
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...
JOURNAL OF EXPERIMENTAL MEDICINE
2020-06-01
PGC1alpha suppresses prostate cancer cell invasion through ERRalpha transcriptional control.
Valcarcel-Jimenez, Lorea; Macchia, Alice; Crosas-Molist, Eva; Schaub-Clerigue, Ariane; Camacho, Laura; Martin-Martin, Natalia; Cicogna, Paolo; Viera-Bardon, Cristina; Fernandez-Ruiz, Sonia; ...
Cancer research
2019-10-08
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
Arreal, L;Piva, M;Fernandez, S;Revandkar, A;Clerigue, AS;Villanueva, J;Zabala-Letona, A;Pujana, M;Astobiza, I;Cortazar, AR;Hermanova, I;Bozal-Basterra, L;Arruabarrena-Aristorena, A;Crespo, JR;Valcarcel-Jimenez, ...
Cell death and differentiation
2019-10-01
CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
Cortazar, AR(Cortazar, Ana R.);Torrano, V(Torrano, Veronica);Martin-Martin, N(Martin-Martin, Natalia);Caro-Maldonado, A(Caro-Maldonado, Alfredo);Camacho, L(Camacho, Laura);Hermanova, I(Hermanova, ...
Cancer research
2018-11-01
Integrative analysis of transcriptomics and clinical data uncovers the tumor- suppressive activity of MITF in prostate cancer
Valcarcel-Jimenez, L(Valcarcel-Jimenez, Lorea);Macchia, A(Macchia, Alice);Martin-Martin, N(Martin-Martin, Natalia);Cortazar, AR(Rosa Cortazar, Ana);Schaub-Clerigu, A(Schaub-Clerigu, Ariane);Pujana-Vaquerizo, ...
Cell death & disease
2018-10-11