Ana R Cortazar
Ana R Cortazar
LABORATORY TECHNICIAN
Cancer Cell Signaling And Metabolism Lab & Genome Analysis Platform
Email: acortazar@cicbiogune.es
Phone: 4468
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)
Latest Publications
PGC1alpha suppresses prostate cancer cell invasion through ERRalpha transcriptional control.
Valcarcel-Jimenez, Lorea; Macchia, Alice; Crosas-Molist, Eva; Schaub-Clerigue, Ariane; Camacho, Laura; Martin-Martin, Natalia; Cicogna, Paolo; Viera-Bardon, Cristina; Fernandez-Ruiz, Sonia; ...
CANCER RESEARCH
2019-10-08

2018

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
Cortazar, AR(Cortazar, Ana R.);Torrano, V(Torrano, Veronica);Martin-Martin, N(Martin-Martin, Natalia);Caro-Maldonado, A(Caro-Maldonado, Alfredo);Camacho, L(Camacho, Laura);Hermanova, I(Hermanova, ...
CANCER RESEARCH
2018-11-01
Integrative analysis of transcriptomics and clinical data uncovers the tumor- suppressive activity of MITF in prostate cancer
Valcarcel-Jimenez, L(Valcarcel-Jimenez, Lorea);Macchia, A(Macchia, Alice);Martin-Martin, N(Martin-Martin, Natalia);Cortazar, AR(Rosa Cortazar, Ana);Schaub-Clerigu, A(Schaub-Clerigu, Ariane);Pujana-Vaquerizo, ...
CELL DEATH & DISEASE
2018-10-11
Cluster Locator, online analysis and visualization of gene clustering
Obregon, FP(Obregon, Flavio Pazos);Soto, P(Soto, Pablo);Lavin, JL(Lavin, Jose Luis);Cortazar, AR(Cortazar, Ana Rosa);Barrio, R(Barrio, Rosa);Aransay, AM(Aransay, Ana Maria);Cantera, R(Cantera, ...
BIOINFORMATICS
2018-10-01
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
Clos-Garcia, M(Clos-Garcia, Marc);Loizaga-Iriarte, A(Loizaga-Iriarte, Ana);Zuniga-Garcia, P(Zuniga-Garcia, Patricia);Sanchez-Mosquera, P(Sanchez-Mosquera, Pilar);Cortazar, AR(Rosa Cortazar, ...
JOURNAL OF EXTRACELLULAR VESICLES
2018-05-07
PPAR delta Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth
Martin-Martin, N(Martin-Martin, Natalia);Zabala-Letona, A(Zabala-Letona, Amaia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Arreal, L(Arreal, Leire);Camacho, L(Camacho, Laura);Castillo-Martin, ...
CANCER RESEARCH
2018-01-15
Low-dose statin treatment increases prostate cancer aggressiveness
Caro-Maldonado, A(Caro-Maldonado, Alfredo);Camacho, L(Camacho, Laura);Zabala-Letona, A(Zabala-Letona, Amaia);Torrano, V(Torrano, Veronica);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Zamacola-Bascaran, ...
ONCOTARGET
2018-01-05

2017

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Zabala-Letona, A(Zabala-Letona, Amaia);Arruabarrena-Aristorena, A(Arruabarrena-Aristorena, Amaia);Martin-Martin, N(Martin-Martin, Natalia);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Sutherland, ...
NATURE
2017-07-06
A fistful of tips for a fruitful high throughput sequencing experiment
Lavin, JL(Lavin, Jose L.);Sanchez-Moran, M(Sanchez-Moran, Mirian);Barcena, L(Barcena, Laura);Cortazar, AR(Cortazar, Ana R.);Macias-Camara, N(Macias-Camara, Nuria);Gonzalez, M(Gonzalez, Monika);Aransay, ...
BIOESSAYS : NEWS AND REVIEWS IN MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY
2017-05-01
VerSeDa: vertebrate secretome database
Cortazar, AR(Cortazar, Ana R.);Oguiza, JA(Oguiza, Jose A.);Aransay, AM(Aransay, Ana M.);Lavin, JL(Lavin, Jose L.)
DATABASE : THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
2017-02-24
Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases.
Goicoechea I; Rezola R; Arestin M; M Caffarel M; Cortazar AR; Manterola L; Fernandez-Mercado M; Armesto M; Sole C; Larrea E; M Araujo A; Ancizar N; Plazaola A; Urruticoechea A; ...
F1000RESEARCH
2017-01-01

2016

Stratification and therapeutic potential of PML in metastatic breast cancer
Martin-Martin, N(Martin-Martin, Natalia);Piva, M(Piva, Marco);Urosevic, J(Urosevic, Jelena);Aldaz, P(Aldaz, Paula);Sutherland, JD(Sutherland, James D.);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Arreal, ...
NATURE COMMUNICATIONS
2016-08-01
The metabolic co-regulator PGC1 alpha suppresses prostate cancer metastasis
Torrano, V(Torrano, Veronica);Valcarcel-Jimenez, L(Valcarcel-Jimenez, Lorea);Cortazar, AR(Rosa Cortazar, Ana);Liu, XJ(Liu, Xiaojing);Urosevic, J(Urosevic, Jelena);Castillo-Martin, M(Castillo-Martin, ...
NATURE CELL BIOLOGY
2016-06-01
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
Royo, F(Royo, Felix);Zuniga-Garcia, P(Zuniga-Garcia, Patricia);Torrano, V(Torrano, Veronica);Loizaga, A(Loizaga, Ana);Sanchez-Mosquera, P(Sanchez-Mosquera, Pilar);Ugalde-Olano, A(Ugalde-Olano, ...
ONCOTARGET
2016-02-09

2015

PECAS: prokaryotic and eukaryotic classical analysis of secretome
Cortazar, AR(Cortazar, Ana R.);Oguiza, JA(Oguiza, Jose A.);Aransay, AM(Aransay, Ana M.);Lavin, JL(Lavin, Jose L.)
AMINO ACIDS
2015-12-01
Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN
Ugalde-Olano, A(Ugalde-Olano, Aitziber);Egia, A(Egia, Ainara);Fernandez-Ruiz, S(Fernandez-Ruiz, Sonia);Loizaga-Iriarte, A(Loizaga-Iriarte, Ana);Zuniga-Garcia, P(Zuniga-Garcia, Patricia);Garcia, ...
METHODS
2015-05-01

2014

SECRETOOL: integrated secretome analysis tool for fungi.
Cortazar, Ana R.; Aransay, Ana M.; Alfaro, Manuel; Oguiza, Jose A.; Lavin, Jose L.
AMINO ACIDS
2014-02-01

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

H-1 NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Bruzzone, C;Loizaga-Iriarte, A;Sanchez-Mosquera, P;Gil-Redondo, R;Astobiza, I;Diercks, T;Cortazar, AR;Ugalde-Olano, A;Schafer, H;Blanco, FJ;Unda, M;Cannet, C;Spraul, M;Mato, JM;Embade, N;Carracedo, ...

JOURNAL OF PROTEOME RESEARCH

2020-06-05

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Hermanova, I;Zuniga-Garcia, P;Caro-Maldonado, A;Fernandez-Ruiz, S;Salvador, F;Martin-Martin, N;Zabala-Letona, A;Nunez-Olle, M;Torrano, V;Camacho, L;Lizcano, JM;Talamillo, A;Carreira, S;Gurel, ...

JOURNAL OF EXPERIMENTAL MEDICINE

2020-06-01

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

Feu, S;Unzueta, F;Llopis, A;Semple, JI;Ercilla, A;Guaita-Esteruelas, S;Jaumot, M;Freire, R;Agell, N

FASEB JOURNAL

2020-05-01

Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media

Plou, J;Garcia, I;Charconnet, M;Astobiza, I;Garcia-Astrain, C;Matricardi, C;Mihi, A;Carracedo, A;Liz-Marzan, LM

ADVANCED FUNCTIONAL MATERIALS

2020-03-05

The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer

Sole, C;Goicoechea, I;Goni, A;Schramm, M;Armesto, M;Arestin, M;Manterola, L;Tellaetxe, M;Alberdi, A;Nogueira, L;Roumiguie, M;Lopez, JI;Jaka, JPS;Urruticoechea, A;Vergara, I;Loizaga-Iriarte, ...

CANCERS

2020-02-22

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

Ercilla, A;Benada, J;Amitash, S;Zonderland, G;Baldi, G;Somyajit, K;Ochs, F;Costanzo, V;Lukas, J;Toledo, L

CELL REPORTS

2020-02-18

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.

Palomo-Irigoyen, Marta; Perez-Andres, Encarni; Iruarrizaga-Lejarreta, Marta; Barreira-Manrique, Adrian; Tamayo-Caro, Miguel; Vila-Vecilla, Laura; Moreno-Cugnon, Leire; Beitia, Nagore; Medrano, ...

journal of clinical investigation

2020-01-15

Arkaitz Carracedo: If the scientific question is good, the result will be interesting

Houston, S;Carracedo, A

JOURNAL OF EXPERIMENTAL MEDICINE

2019-11-01

rMTA: robust metabolic transformation analysis

Valcarcel, LV;Torrano, V;Tobalina, L;Carracedo, A;Planes, FJ

Bioinformatics (Oxford, England)

2019-11-01

PGC1alpha suppresses prostate cancer cell invasion through ERRalpha transcriptional control.

Valcarcel-Jimenez, Lorea; Macchia, Alice; Crosas-Molist, Eva; Schaub-Clerigue, Ariane; Camacho, Laura; Martin-Martin, Natalia; Cicogna, Paolo; Viera-Bardon, Cristina; Fernandez-Ruiz, Sonia; ...

Cancer research

2019-10-08

Latest Publications

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

Lapitz, A;Arbelaiz, A;O'Rourke, CJ;Lavin, JL;La Casta, A;Ibarra, C;Jimeno, JP;Santos-Laso, A;Izquierdo-Sanchez, L;Krawczyk, M;Perugorria, MJ;Jimenez-Aguero, R;Sanchez-Campos, A;Riano, I;Gonzalez, ...

CELLS

2020-03-14

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.

Palomo-Irigoyen, Marta; Perez-Andres, Encarni; Iruarrizaga-Lejarreta, Marta; Barreira-Manrique, Adrian; Tamayo-Caro, Miguel; Vila-Vecilla, Laura; Moreno-Cugnon, Leire; Beitia, Nagore; Medrano, ...

journal of clinical investigation

2020-01-15

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

Janin, M;Ortiz-Barahona, V;de Moura, MC;Mart?nez-Card?s, A;Llin?s-Arias, P;Soler, M;Nachmani, D;Pelletier, J;Schumann, U;Calleja-Cervantes, ME;Moran, S;Guil, S;Bueno-Costa, A;Pi?eyro, D;Perez-Salvia, ...

ACTA NEUROPATHOLOGICA

2019-12-01

Intestinal epithelial deletion of the glucocorticoid receptor NR3C1 alters expression of inflammatory mediators and barrier function.

Aranda, Carlos J; Arredondo-Amador, Maria; Ocon, Borja; Lavin, Jose Luis; Aransay, Ana Maria; Martinez-Augustin, Olga; Sanchez de Medina, Fermin

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2019-10-26

Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

Rodriguez, RM;Suarez-Alvarez, B;Lavin, JL;Ascension, AM;Gonzalez, M;Lozano, JJ;Raneros, AB;Bulnes, PD;Vidal-Castineira, JR;Huidobro, C;Martin-Martin, C;Sanz, AB;Ruiz-Ortega, M;Puig-Kroger, A;Corbi, ...

CELL REPORTS

2019-10-22

Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia

Clos-Garcia, M;Andres-Marin, N;Fernandez-Eulate, G;Abecia, L;Lavin, JL;van Liempd, S;Cabrera, D;Royo, F;Valero, A;Errazquin, N;Vega, MCG;Govillard, L;Tackett, MR;Tejada, G;Gonzalez, E;Anguita, ...

EBIOMEDICINE

2019-08-01

ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach

Loren, V;Garcia-Jaraquemada, A;Naves, JE;Carmona, X;Manosa, M;Aransay, AM;Lavin, JL;Sanchez, I;Cabre, E;Manye, J;Domenech, E

J Crohns Colitis

2019-03-01

A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice

Prieto-Fernandez, E;Aransay, AM;Royo, F;Gonzalez, E;Lozano, JJ;Santos-Zorrozua, B;Macias-Camara, N;Gonzalez, M;Garay, RP;Benito, J;Garcia-Orad, A;Falcon-Perez, JM

THERANOSTICS

2019-01-01

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Cortazar, AR(Cortazar, Ana R.);Torrano, V(Torrano, Veronica);Martin-Martin, N(Martin-Martin, Natalia);Caro-Maldonado, A(Caro-Maldonado, Alfredo);Camacho, L(Camacho, Laura);Hermanova, I(Hermanova, ...

Cancer research

2018-11-01

Integrative analysis of transcriptomics and clinical data uncovers the tumor- suppressive activity of MITF in prostate cancer

Valcarcel-Jimenez, L(Valcarcel-Jimenez, Lorea);Macchia, A(Macchia, Alice);Martin-Martin, N(Martin-Martin, Natalia);Cortazar, AR(Rosa Cortazar, Ana);Schaub-Clerigu, A(Schaub-Clerigu, Ariane);Pujana-Vaquerizo, ...

Cell death & disease

2018-10-11