2010/09/07 12:00

ATRIO 800

Prof. Dennis Vance (University of Alberta, Canada)

Inhibition of phospholipid methylation protects against atherosclerosis and diet-induced obesity

  Short Biography Dennis E. Vance is a University Professor and Professor of Biochemistry at the University of Alberta. He did his Ph.D. at the University of Pittsburgh supervised by Charles Sweeley. He did postdoctoral training at Harvard University with Konrad Bloch. He was Professor and Chair of the Department of Biochemistry at the University of British Columbia (1982-86) and Associate Dean of Medicine (1978 -81). He moved to the University of Alberta in 1986 to establish a Lipid Research Group. He was Director of the SCOLAR (Stroke, Cardiovascular, Obesity, Lipid, Atherosclerosis Research) Training Program from CIHR and the Heart and Stroke Foundation of Canada.  He has served on CIHR committees including Chair of the Metabolism Committee. He is Principal Investigator on two grants from CIHR. His research on mammalian phosphatidylcholine metabolism has been recognized by the Boehringer Mannheim Canada Prize of the Canadian Biochemical Society in 1989, the Heinrich Wieland Prize awarded in 1995 in Munich, Germany, election as Fellow of the Royal Society of Canada (1996), a Canada Research Chair (2002), the Avanti Award from the American Society of Biochemistry and Molecular Biology (2006) and the Kaplan Award from the University of Alberta (2009). He presented the Laurens van Deenen lecture at the 2008 meeting of the International Conference on the Bioscience of Lipids. He was awarded the 2010 Tier I Basic Science Mentoring Award by the Faculty of Medicine at the University of Alberta. He co-authored with Geoff Zubay Principles of Biochemistry, an introductory biochemistry textbook and co-edited with Jean Vance five editions of an advanced textbook, Biochemistry of Lipids, Lipoproteins and Membranes. The fifth edition was published in March, 2008. He was an Executive Editor of the international journal BBA for 9 years. Prof. Vance became Editor in Chief of BBA in January, 2007.

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2010/09/09 12:00

ATRIO 800

Irene Díaz Moreno, PhD (Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla - CSIC.)

The role of K-homology Splicing Recognition Protein

K-homology Splicing Regulator Protein (KSRP) is a multi-domain RNA-binding proteininvolved in gene regulation by promoting adenosine-uridine-rich element (ARE)-mediated mRNA decay (AMD). Post-translationally modified KSRP by phosphorylation of a serine residue from the first RNA-binding domain (KH1) becomes unfolded and transiently recognised by the 14-3-3ζ protein, which efficiently discriminates between phosphorylated and unphosphosrylated KSRP-KH1, driving the nuclear localization of KSRP. In addition, the arrangement of the two central KSRP RNA-binding domains (KH2-KH3) by the linker between them has important implications for discriminating between KSRP´s RNA targets.

2010/09/10 12:00

ATRIO 800

MONTSE SANCHEZ-CESPEDES, PhD (Institut Investigacions Biomediques Bellvitge-IDIBELL-PEBC. Barcelona)

LKB1 AND BRG1, TALES OF TWO TUMOR SUPPRESSOR GENES ON CHROMOSOME 19p AND HUMAN LUNG CANCER

Lung cancer is the most common cause of cancer deaths worldwide, with over one million cases annually. In addition to preventing uptake and encouraging cessation of the smoking habit, it is important to invest in understanding the biology of this type of cancer. Several gene alterations contribute to the development of lung cancer, including activating mutations, gene translocation and gene amplification at oncogenes as well as inactivating point mutations, homozygous deletions or promoter hypermethylation at tumor suppressor genes. Losses of heterozygosity (LOH) at chromosome 19p are frequent in lung cancer, suggesting that one or more tumor suppressor genes are contained in this region.

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2010/09/17 12:00

ATRIO 800

Christian Smerdou (CIMA. Universidad de Navarra)

"Use of alphavirus vectors for cancer treatment"

2010/09/24 12:00

ATRIO 800

MARIA LOIS, PhD (Center for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB)

TBA

2010/10/01 12:00

ATRIO 800

PAUL FRASER, PhD (UNIVERSITY OF TORONTO, CANADA)

TBA

2010/10/08 12:00

ATRIO 800

Dr. Fernando Rodriguez (CReSA. Barcelona)

TBA

2010/10/22 12:00

ATRIO 800

IVAN DIKIC, PhD (GOETHE UNIVERSITY SCHOOL OF MEDICINE, FRANKFURT)

TBA

2010/10/29 12:00

ATRIO 800

DANIEL NIETLISPACH, PhD (University of Cambridge)

TBA

2011/03/11 12:00

ATRIO 800

PROF. PETER GÜNTERT

TBA