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This work has lead to the structure determination of several protein complexes (ESCRT-II, ESCRT-I, Bro1 domain, RETROMER) that have been published among the top impact factor scientific journals.
Since 2008 he is continuing his work in protein trafficking as group leader at the Cooperative Research Centre-CIC bioGUNE.
The philosophy of the group is to accomplish current biological questions through different perspectives and establishment of close collaborations with other disciplines.
Research Units
Structural Biology Unit - Laboratory 3
Personal data
Following bachelor’s degree Aitor Hierro started his PhD studies in the Biochemistry & Molecular Biology department of Basque Country University/EHU under the supervision of Prof. Arturo Muga and Adelina Prado. The aim of the work was to characterize the relationship between structure and function of a chaperon called Nucleoplasmin. In 2002 he completed his PhD with the maximum qualification. As post-graduate he worked in Dr. James H. Hurley’s group at the National Institutes of Health (USA). His interest is focus on very challenging projects concerning large multiprotein complexes involved in cell trafficking. His research project is divided in two mayor areas: (1) Developing new procedures for protein complexes expression and screening, witch have already been successfully adopted by other researchers and (2) Taking a combination of approaches to study large multiprotein complexes with special weigh in Structural Biology using X-Ray crystallography.
This work has lead to the structure determination of several protein complexes (ESCRT-II, ESCRT-I, Bro1 domain, RETROMER) that have been published among the top impact factor scientific journals.
Since 2008 he is continuing his work in protein trafficking as group leader at the Cooperative Research Centre-CIC bioGUNE.
The philosophy of the group is to accomplish current biological questions through different perspectives and establishment of close collaborations with other disciplines.
Selected Publications
Hierro A, Rojas AL, Rojas R, Murthy N, Effantin G, Kajava AV, Steven AC, Bonifacino JS, Hurley JH; Functional architecture of the retromer cargo-recognition complex. Nature 25, 449, 1063-1067 (2007).
