Support Units
Animal Facilities Unit
The CIC bioGUNE´s Animal Unit (AU) is an AAALAC accredited facility which includes a Specific Pathogen Free (SPF) area to house rodents from commercial sources and to produce and keep some strains of genetically engineered mice (GEM).
The main functions of the Animal facilities Unit are listed below.
- 1. Providing the users with the assessment and equipment necessary to carry out their research on laboratory animals.
- 2. Providing care and assuring the welfare of laboratory animals; carrying out periodic health monitoring tests.
- 3. Ensuring observance of all legal and ethical standards concerning the use of animals for research and other scientific ends.
The AU works for the continuing improvement in their services and also engages in the development of new services through the collaboration with researchers from different areas of interest. With this in mind, our main objective for the coming months is focused on the use of ultrasounds (echography) to detect liver lesions in murine models of steatosis and hepatic tumours. In addition, preliminary echocardiography assays are being developed in order to assess the heart function in new strains of GEM.
Principal Investigator
- Email: janguita@cicbiogune.es
- Phone: 944.061.311 (EXT. 211)
- Address: Parque Tecnológico de Vizcaya
Ed. 801A Derio (Vizcaya)
Laboratory members
Publications
Fernández-Domínguez I, Echevarria-Uraga JJ, Gómez N, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, Rodríguez-Cuesta J; High-frequency ultrasound imaging for longitudinal evaluation of non-alcoholic fatty liver disease progression in mice.. Ultrasound Med Biol 37, 7 1161-9 (2011)
Fernández I, Peña A, Del Teso N, Pérez V and Rodríguez-Cuesta J; Clinical Biochemistry Parameters in C57BL/6J Mice after Blood Collection from the Submandibular Vein and Retroorbital Plexus. J Am Assoc Lab Anim Sci 49, 2 202-6 (2010)
Rodríguez-Cuesta J, Martínez-de-Tejada G, Hernando L.F., Mendoza L, Gallot N, Díaz de Cerio A.A. and Vidal-Vanaclocha F ; Candida albicans Enhances Experimental Hepatic Melanoma Metastasis. Clin Exp Metastasis 27, 1 35-42 (2010)
Varela-Rey M, Fernández-Ramos D, Martínez-López N, Embade N, Gómez-Santos L, Beraza N, Vázquez-Chantada M, Rodríguez J, Luka Z, Wagner C, Lu SC, Martínez-Chantar ML, Mato JM.; Impaired liver regeneration in mice lacking glycine N-methyltransferase. Hepatology 50, 2 4443-4452 (2009)
Martínez-Chantar M.L., Vázquez-Chantada M., Ariz U., Martínez N., Varela M., Luka Z., Capdevila A., Rodriguez J., Aransay A.M., Matthiesen R., Yang H., Calvisi D.F., Esteller M,. Fraga M., Lu S.C., Wagner C., Mato J.M.; Loss of the Glycine N-Methyltransferase Gene Leads to Steatosis and Hepatocellular Carcinoma in Mice. Hepatology 47, 4 1191-9 (2008)